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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $700 | 6-8 weeks | |
5 mg | $1,800 | 6-8 weeks |
Description | Carabersat(SB 204269) is a novel and effective anticonvulsant and antiepileptic agent. |
Targets&IC50 | Forebrain membranes:7.3 (pKi,rat), Forebrain membranes:40 nM (Kd,rat), Forebrain membranes:53 nM (Kd,mouse) |
In vitro | [3H]Carabersat ([3H]SB 204269) binds to rat forebrain membranes with moderate affinity (Kd 40 nM) and pKi values of 7.3[1]. In mouse forebrain membranes, Carabersat is able to bind, and the binding is saturable and stereospecific, with a Kd of 53 nM. The labeled [3H]Carabersat produces a Kd of 32 nM[2]. Carabersat (SB-204269, 1-100 μM) has no effect on Na+ current in cultured hippocampal neurons. It also shows no effect on action potential discharges evoked by elevating external K+[4]. Structurally related to the benzopyran ATP-sensitive potassium channel (KATP) opener cromakalim, Carabersat (SB-204269) has opposite stereochemistry, and its mechanism of action is not thought to involve KATP[3]. |
In vivo | Significantly elevating anticonvulsant activity in mice, Carabersat (5b) has been observed[1]. |
Alias | SB 204269 |
Molecular Weight | 357.38 |
Formula | C20H20FNO4 |
Cas No. | 184653-84-7 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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