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CAY10597

Catalog No. T38365Cas No. 916046-55-4

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM.

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Pack Size	Price	Availability
1 mg	$178	35 days
5 mg	$783	35 days
10 mg	$1,380	35 days

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	416.79
Formula	C20H14ClFN2O5
Cas No.	916046-55-4

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	Ethanol: 20 mg/mL PBS (pH 7.2): 0.30 mg/mL DMF: 30 mg/mL DMSO: 30 mg/mL

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