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CBB1003 hydrochloride (1379573-88-2 free base)
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Catalog No. T10698L
Alias CBB1003 hydrochloride
CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).
CBB1003 hydrochloride (1379573-88-2 free base)
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Catalog No. T10698LAlias CBB1003 hydrochloride
CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM). |
| In vitro | In mouse embryonic teratocarcinoma F9 cells, treatment of CBB1003 led to significant growth inhibition and the activation of CHRM4 and SCN3A expression. Treatment of mouse ES cells with CBB1003 also led to substantial inhibition of the spherical growth of ES cells [1]. CBB1003 inhibited CRC cell proliferation and colony formation. In cultured CRC cells, inhibiting LSD1 activity by CBB1003 caused a decrease in LGR5 levels while overexpression of LGR5 reduced CBB1003-induced cell death [2]. |
| Alias | CBB1003 hydrochloride |
| Molecular Weight | 703.88 |
| Formula | C25H36Cl5N9O4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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