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CBR-470-2

Name: CBR-470-2
Brand: TargetMol
SKU: T36037
Price: 42 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T36037Cas No. 2416095-00-4

CBR-470-2, a glycine-substituted analog, activates NRF2 signaling, making it valuable for investigating glycolysis modulation in scientific research [1].

CBR-470-2

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Catalog No. T36037Cas No. 2416095-00-4

CBR-470-2, a glycine-substituted analog, activates NRF2 signaling, making it valuable for investigating glycolysis modulation in scientific research [1].

Pack Size	Price	Availability	Quantity
5 mg	$456	7-10 days

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Product Introduction

Bioactivity

Description	CBR-470-2, a glycine-substituted analog, activates NRF2 signaling, making it valuable for investigating glycolysis modulation in scientific research [1].
In vitro	CBR-470-2 (1-10 μM; 24 h) upregulates NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].
In vivo	CBR-470-2 (50 mg/kg; p.o. twice daily for 10 days) induces activation of NRF2 signaling in vivo. Animal Model: Balb/C mice (5-week old) exposed to UVB.

Chemical Properties

Molecular Weight	402.26
Formula	C₁₂H₁₃Cl₂NO₆S₂
Cas No.	2416095-00-4
Relative Density.	1.71 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (497.18 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4860 mL	12.4298 mL	24.8595 mL	124.2977 mL
5 mM	0.4972 mL	2.4860 mL	4.9719 mL	24.8595 mL
10 mM	0.2486 mL	1.2430 mL	2.4860 mL	12.4298 mL
20 mM	0.1243 mL	0.6215 mL	1.2430 mL	6.2149 mL
50 mM	0.0497 mL	0.2486 mL	0.4972 mL	2.4860 mL
100 mM	0.0249 mL	0.1243 mL	0.2486 mL	1.2430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CBR-470-2CBR4702CBR 470 2