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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $52 | 5 days |
Description | CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |
Targets&IC50 | CCR2b:180 nM |
In vitro | Ile263 and Thr292 in CCR2 significantly contribute to the binding of CCR2 antagonist 4. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride. Additionally, Glu291 in TM7 substantially impacts the binding of the protonated CCR2 antagonist 4 hydrochloride and CCL2 [2]. |
In vivo | In ApoE-deficient mice, CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta [3]. |
Alias | Teijin compound 1 hydrochloride |
Molecular Weight | 476.32 |
Formula | C21H22Cl2F3N3O2 |
Cas No. | 1313730-14-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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