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CCR2 antagonist 4 hydrochloride
Catalog No. T19230Cas No. 1313730-14-1
Alias Teijin compound 1 hydrochloride
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
CCR2 antagonist 4 hydrochloride
Catalog No. T19230Alias Teijin compound 1 hydrochlorideCas No. 1313730-14-1
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). |
| Targets&IC50 | CCR2b:180 nM |
| In vitro | Ile263 and Thr292 in CCR2 significantly contribute to the binding of CCR2 antagonist 4. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride. Additionally, Glu291 in TM7 substantially impacts the binding of the protonated CCR2 antagonist 4 hydrochloride and CCL2 [2]. |
| In vivo | In ApoE-deficient mice, CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta [3]. |
| Alias | Teijin compound 1 hydrochloride |
| Molecular Weight | 476.32 |
| Formula | C21H22Cl2F3N3O2 |
| Cas No. | 1313730-14-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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