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CCR2 antagonist 4

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COA HNMR LCMS

CCR2 antagonist 4

Catalog No. T13114Cas No. 226226-39-7

CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).

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Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$187	In Stock
10 mg	$278	In Stock
25 mg	$469	In Stock
50 mg	$677	In Stock
100 mg	$943	In Stock
500 mg	$1,880	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).
In vivo	Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta in ApoE-deficient mice[3].
Alias	Teijin compound 1

Chemical Properties

Molecular Weight	439.86
Formula	C21H21ClF3N3O2
Cas No.	226226-39-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (113.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2735 mL	11.3673 mL	22.7345 mL	113.6725 mL
5 mM	0.4547 mL	2.2735 mL	4.5469 mL	22.7345 mL
10 mM	0.2273 mL	1.1367 mL	2.2735 mL	11.3673 mL
20 mM	0.1137 mL	0.5684 mL	1.1367 mL	5.6836 mL
50 mM	0.0455 mL	0.2273 mL	0.4547 mL	2.2735 mL
100 mM	0.0227 mL	0.1137 mL	0.2273 mL	1.1367 mL

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