Shopping Cart
- Remove All
Your shopping cart is currently empty
Bindarit
Catalog No. T6413Cas No. 130641-38-2
Alias AF2838
Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters.
Bindarit
Catalog No. T6413Alias AF2838Cas No. 130641-38-2
Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $125 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $332 | In Stock | |
| 50 mg | $496 | In Stock | |
| 100 mg | $712 | In Stock | |
| 500 mg | $1,460 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $139 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Bindarit"
Artemotil
Cited
β-Arteether, SM-227, Beta-Arteether, Arteether, (+)-Arteether
T332775887-54-6
Artemotil (SM-227) is a new, fast-acting antimalarial drug.
- $50
Size
QTY
Cited7,4'-Dihydroxyflavone
4',7-Dihydroxyflavone
TN12732196-14-7
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
- $33
Size
QTY
Eburicoic acid
ZINC4655149, MFCD00238594, Eburicoicacid
TN1599560-66-7
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer.
- $76
Size
QTY
Select Batch
Purity:98.71%
Contact us for more batch information
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters. |
| In vitro | METHODS: Raw 264.7 cells were stimulated with LPS (1 μg/ml) at different time points (1, 2, 4, 8, and 24 h) with bindarit (AF2838) (300 μM, 1 h before treatment) to investigate the mechanism by which bindarit exerts its anti-inflammatory effects. RESULTS Bindarit pretreatment significantly reduced MCP-1 mRNA levels, and at the highest LPS-induced peak (4 h), MCP-2 and MCP-3 gene expressions were inhibited by 24% and 36%, respectively. [1] |
| In vivo | METHODS: Bindarit (AF2838) (200 μg/g) was used to treat the OVX mouse model to verify the expression of CCL2 and CCL7. RESULTS Bindarit attenuated the expression of CCL2 and CCL7 in the OVX mouse model. [2] |
| Alias | AF2838 |
| Molecular Weight | 324.37 |
| Formula | C19H20N2O3 |
| Cas No. | 130641-38-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 25 mg/mL (77.1 mM) DMSO: 45 mg/mL (138.73 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
| |||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Bindarit | purchase Bindarit | Bindarit cost | order Bindarit | Bindarit chemical structure | Bindarit in vivo | Bindarit in vitro | Bindarit formula | Bindarit molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.