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Bindarit
🥰Excellent
Catalog No. T6413Cas No. 130641-38-2
Alias AF2838
Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters.
Bindarit
🥰Excellent
Purity: 98.71%
Catalog No. T6413Alias AF2838Cas No. 130641-38-2
Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $125 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $332 | In Stock | |
| 50 mg | $496 | In Stock | |
| 100 mg | $712 | In Stock | |
| 500 mg | $1,460 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $139 | In Stock |
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Purity:98.71%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8 with anti-inflammatory effects. Bindarit specifically inhibits p65- and p65/p50-induced MCP-1 promoter activation and has no effect on other tested activated promoters. |
| In vitro | METHODS: Raw 264.7 cells were stimulated with LPS (1 μg/ml) at different time points (1, 2, 4, 8, and 24 h) with bindarit (AF2838) (300 μM, 1 h before treatment) to investigate the mechanism by which bindarit exerts its anti-inflammatory effects. RESULTS Bindarit pretreatment significantly reduced MCP-1 mRNA levels, and at the highest LPS-induced peak (4 h), MCP-2 and MCP-3 gene expressions were inhibited by 24% and 36%, respectively. [1] |
| In vivo | METHODS: Bindarit (AF2838) (200 μg/g) was used to treat the OVX mouse model to verify the expression of CCL2 and CCL7. RESULTS Bindarit attenuated the expression of CCL2 and CCL7 in the OVX mouse model. [2] |
| Alias | AF2838 |
| Molecular Weight | 324.37 |
| Formula | C19H20N2O3 |
| Cas No. | 130641-38-2 |
| Smiles | CC(C)(OCc1nn(Cc2ccccc2)c2ccccc12)C(O)=O |
| Relative Density. | 1.18g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 25 mg/mL (77.1 mM) DMSO: 45 mg/mL (138.73 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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