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CCR7 Ligand 1

Catalog No. T10716Cas No. 681514-83-0

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

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Pack Size	Price	Availability
25 mg	$1,870	10-14 weeks
50 mg	$2,440	10-14 weeks
100 mg	$3,690	10-14 weeks

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Product Introduction

Bioactivity

Description	CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM
In vitro	CCR7 Ligand 1 (CCR7-Cmp2105) specifically targets and binds to a distinct site within the intracellular domain of CCR7, located between the terminal regions of transmembrane segments TM1, TM2, TM3, and TM6, as well as the loop linking TM7 and helix 8 [1]. This interaction allosterically impedes the attachment of the natural chemokine CCL19 to CCR7, evidenced by an inhibition concentration (IC50) of 35 nM in scintillation proximity assays (bottom) [1]. Additionally, the application of CCR7 Ligand 1 at varying concentrations (20, 40, 60, 80, 100 μM) demonstrates a concentration-dependent enhancement of CCR7's thermal stability [1].
Alias	CCR7-Cmp2105

Chemical Properties

Molecular Weight	475.56
Formula	C22H29N5O5S
Cas No.	681514-83-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (26.28 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1028 mL	10.5139 mL	21.0278 mL	105.1392 mL
5 mM	0.4206 mL	2.1028 mL	4.2056 mL	21.0278 mL
10 mM	0.2103 mL	1.0514 mL	2.1028 mL	10.5139 mL
20 mM	0.1051 mL	0.5257 mL	1.0514 mL	5.2570 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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