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CCR7 Ligand 1

Name: CCR7 Ligand 1
Brand: TargetMol
SKU: T10716
Price: 32 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10716Cas No. 681514-83-0

Alias CCR7-Cmp2105

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. This thiadiazole-dioxide ligand suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.

CCR7 Ligand 1

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Catalog No. T10716Alias CCR7-Cmp2105Cas No. 681514-83-0

Pack Size	Price	Availability
2 mg	$1,478	10-14 weeks
5 mg	$2,089	10-14 weeks
25 mg	$8,465	10-14 weeks
50 mg	$6,329	10-14 weeks
100 mg	$11,780	10-14 weeks

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Product Introduction

Bioactivity

Description	CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. This thiadiazole-dioxide ligand suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.
Targets&IC50	CCR7 (human):3 nM (kd)
In vitro	CCR7 Ligand 1 (CCR7-Cmp2105) binds specifically to the intracellular domain of CCR7 between transmembrane segments TM1, TM2, TM3, and TM6, and the loop linking TM7 and helix 8 [1]. This binding allosterically inhibits CCL19 binding to CCR7 with an IC50 of 35 nM in scintillation proximity assays (bottom) [1], and varying concentrations (20, 40, 60, 80, 100 μM) of CCR7 Ligand 1 enhance CCR7's thermal stability concentration-dependently [1].
Alias	CCR7-Cmp2105

Chemical Properties

Molecular Weight	475.56
Formula	C₂₂H₂₉N₅O₅S
Cas No.	681514-83-0
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 12.5 mg/mL (26.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1028 mL	10.5139 mL	21.0278 mL	105.1392 mL
5 mM	0.4206 mL	2.1028 mL	4.2056 mL	21.0278 mL
10 mM	0.2103 mL	1.0514 mL	2.1028 mL	10.5139 mL
20 mM	0.1051 mL	0.5257 mL	1.0514 mL	5.2570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CCR7 Ligand 1CCR-7 Ligand 1