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CDK4/6-IN-5

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Catalog No. T39956Cas No. 2380321-50-4
Alias CDK4/6-IN-5

CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 nM for CDK4/Cyclin D1 and 4.4 nM for CDK6/Cyclin D3 (WO2019207463A1, example A93).

CDK4/6-IN-5

CDK4/6-IN-5

😃Good
Catalog No. T39956Alias CDK4/6-IN-5Cas No. 2380321-50-4
CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 nM for CDK4/Cyclin D1 and 4.4 nM for CDK6/Cyclin D3 (WO2019207463A1, example A93).
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Product Introduction

Bioactivity
Description
CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 nM for CDK4/Cyclin D1 and 4.4 nM for CDK6/Cyclin D3 (WO2019207463A1, example A93).
In vitro
The CDK4/6 inhibitor, CDK4/6-IN-5, exhibits cell-based IC50 values of 23.8 nM and 61.4 nM against JEKO-1 and MV4-11 cells, respectively, targeting CDK4 and CDK6[1].
AliasCDK4/6-IN-5
Chemical Properties
Molecular Weight527.01
FormulaC22H28ClFN6O4S
Cas No.2380321-50-4
Relative Density.1.56 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

CDK4/6IN5CDK4/6 IN 5CDK-4/6-IN-5
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