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CDK5 inhibitor 20-223

Name: CDK5 inhibitor 20-223
Brand: TargetMol
SKU: T36742
Price: 48 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T36742Cas No. 865317-30-2

Alias CDK5 inhibitor 20-223

CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].

CDK5 inhibitor 20-223

😃Good

Catalog No. T36742Alias CDK5 inhibitor 20-223Cas No. 865317-30-2

CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].

Pack Size	Price	Availability
2 mg	$95	5 days
50 mg	$789	6-8 weeks
100 mg	$1,180	6-8 weeks

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Product Introduction

Bioactivity

Description	CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
Targets&IC50	CDK2:6.0 nM (IC50), CDK5:8.8 nM (IC50)
In vitro	CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) effectively inhibits cell growth in a range of colorectal cancer (CRC) cell lines. Additionally, CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO. [1] Cell Viability Assay[1] Cell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells.
In vivo	CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) demonstrates anti-tumor activity in human CRC xenograft tumors in athymic nude mice[1].
Alias	CDK5 inhibitor 20-223

Chemical Properties

Molecular Weight	305.37
Formula	C₁₉H₁₉N₃O
Cas No.	865317-30-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

CDK5 inhibitor 20223CDK5 inhibitor 20 223CDK-5 inhibitor 20-223