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CDK6/9-IN-1

CDK6/9-IN-1
CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.
Catalog No. T40047Cas No. 2414373-55-8
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CDK6/9-IN-1

Catalog No. T40047Alias CDK6/9-IN-1Cas No. 2414373-55-8
CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.
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Product Introduction

Bioactivity
Description
CDK6/9-IN-1 (compound 66) is a potent, orally administered dual inhibitor of CDK6 and CDK9, with IC50 values of 40.5 nM and 39.5 nM, respectively.
Targets&IC50
CDK9:39.5 nM (IC50), CDK6:40.5 nM (IC50)
In vitro
Treatment with CDK6/9-IN-1 (Compound 66, at concentrations of 4 or 8 μM in MDA-MB-231 cells) results in G0/G1 cell cycle arrest, with arrest rates of 71.85% and 77.51%, respectively, compared to the control group's rate of 57.65%[1].
In vivo
Compound 66 (CDK6/9-IN-1) markedly reduces tumor growth in a xenograft mouse model without apparent toxicity. This underscores the promising potential of CDK6/9 dual inhibitors as a therapeutic option for cancer treatment[1].
AliasCDK6/9-IN-1
Chemical Properties
Molecular Weight452.95
FormulaC22H25ClN8O
Cas No.2414373-55-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

CDK-6/9-IN-1CDK6/9 IN 1CDK6/9IN1
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