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CDK7/9-IN-1

Catalog No. T40353Cas No. 2747919-19-1
Alias CDK7/9-IN-1

CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research.

CDK7/9-IN-1

CDK7/9-IN-1

Catalog No. T40353Alias CDK7/9-IN-1Cas No. 2747919-19-1
CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research.
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Product Introduction

Bioactivity
Description
CDK7/9-IN-1 is a specific inhibitor of cyclin-dependent kinases 7/9 (CDK7/9), targeting CDK7 with IC50 values of 0.0656 μM without pre-incubation and 0.00574 μM after 3 hours pre-incubation, and displaying inhibitory activity against CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation, making it valuable for cancer research.
Targets&IC50
CDK7:5.74-65.6 nM (IC50), CDK9:2.14 μM (IC50)
In vitro
CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) selectively inhibits CDK7, CDK9, and cMyc in HCT116 cells, with IC50 values of 0.0262 μM, 2.59 μM, and 0.0138 μM, respectively, for their targeted phospho-carboxyl terminal domains (Rbp2) (Ser5 for CDK7 and Ser2 for CDK9). At concentrations of 20 μM, 2 μM, and 0.2 μM for 1 hour, CDK7/9-IN-1 exhibits exceptional selectivity, inhibiting approximately 96% of CDK7 activity across a panel of 468 protein kinases[1].
AliasCDK7/9-IN-1
Chemical Properties
Molecular Weight479.548
FormulaC24H32F3N5O2
Cas No.2747919-19-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

CDK7/9IN1CDK-7/9-IN-1CDK7/9 IN 1
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