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Cedazuridine hydrochloride

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Catalog No. T60708

Cedazuridine (E7727) (Compound 7a) hydrochloride, an orally active cytidine deaminase (CDA) inhibitor with an IC50 of 0.4 μM, can be used for cancer research [1].

Cedazuridine hydrochloride

Cedazuridine hydrochloride

😃Good
Catalog No. T60708
Cedazuridine (E7727) (Compound 7a) hydrochloride, an orally active cytidine deaminase (CDA) inhibitor with an IC50 of 0.4 μM, can be used for cancer research [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5201-2 weeks
50 mg$1,9801-2 weeks
100 mg$2,5001-2 weeks
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Product Introduction

Bioactivity
Description
Cedazuridine (E7727) (Compound 7a) hydrochloride, an orally active cytidine deaminase (CDA) inhibitor with an IC50 of 0.4 μM, can be used for cancer research [1].
In vitro
Cedazuridine (Compound 7a) demonstrates superior acid stability [1], and at concentrations of 0-10 μM over 72 hours, it does not enhance the growth inhibition effects of AZA (5-Azacytidine) in AML cell lines [2].
In vivo
Cedazuridine, when administered orally at a dose of 3 mg/kg daily for 7 days, in conjunction with 2.5 mg/kg AZA, induced tumor regression in both MOLM-13 cell line-derived (CDX) and patient-derived xenograft (PDX) mouse models of leukemia. Female NSGS mice, aged 6–8 weeks, were used for these experiments, demonstrating not only a reduction in leukemic expansion in synergy with AZA in a CDX setup but also showcasing preliminary safety and efficacy in a primary AML PDX scenario. Further investigations in NSGS male mice, with Cedazuridine doses ranging from 1 to 30 mg/kg combined with 2.5 mg/kg AZA, revealed a dose-dependent increase in the bioavailability (AUC) of orally administered AZA, compared to its standard intraperitoneal administration, suggesting enhanced pharmacokinetic performance.
Chemical Properties
Molecular Weight304.68
FormulaC9H15ClF2N2O5
Storage & Solubility Information
StorageShipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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