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CGP 25454A

Name: CGP 25454A
Brand: TargetMol
SKU: T10779
Rating: 4.5 (1 reviews)

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Catalog No. T10779Cas No. 104391-26-6

CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A).

CGP 25454A

😃Good

Catalog No. T10779Cas No. 104391-26-6

CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A).

Pack Size	Price	Availability
2 mg	$134	5 days
5 mg	$228	5 days
25 mg	$613	6-8 weeks
50 mg	$797	6-8 weeks
100 mg	$1,360	6-8 weeks

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Product Introduction

Bioactivity

Description	CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor (CGP 25454A).
In vitro	CGP 25454A increases the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh.
In vivo	CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). At 30-100 mg/kg, CGP 25454A inhibits [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors.

Chemical Properties

Molecular Weight	346.25
Formula	C₁₅H₂₁Cl₂N₃O₂
Cas No.	104391-26-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 3.5 mg/mL (10.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8881 mL	14.4404 mL	28.8809 mL	144.4043 mL
5 mM	0.5776 mL	2.8881 mL	5.7762 mL	28.8809 mL
10 mM	0.2888 mL	1.4440 mL	2.8881 mL	14.4404 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

CGP 25454A