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CGP78850

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Catalog No. T40219Cas No. 258326-83-9

CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist with potential applications in cancer research.

CGP78850

CGP78850

😃Good
Catalog No. T40219Cas No. 258326-83-9
CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist with potential applications in cancer research.
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25 mg$1,520Backorder
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Product Introduction

Bioactivity
Description
CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist with potential applications in cancer research.
In vitro
CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) exhibits a dose-dependent reduction in Grb2 protein association, inhibiting interactions between EGFR and Grb2 as well as between Shc and Grb2 in living cells. It also prevents MDA-MB-468 cells from forming colonies in soft agar in a dose-dependent manner, confirmed by Western Blot Analysis showing a significant decrease in Grb2 protein levels.
Chemical Properties
Molecular Weight723.764
FormulaC36H46N5O9P
Cas No.258326-83-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

CGP-78850CGP 78850CGP78850
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