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CH2COOH-PEG6-CH2COOH

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Catalog No. T40935Cas No. 83824-29-7
Alias CH2COOH-PEG6-CH2COOH

CH2COOH-PEG6-CH2COOH is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands vital for forming PROTAC molecules. This linker enables selective protein degradation by exploiting the ubiquitin-proteasome system within cells.

CH2COOH-PEG6-CH2COOH

CH2COOH-PEG6-CH2COOH

🥰Excellent
Catalog No. T40935Alias CH2COOH-PEG6-CH2COOHCas No. 83824-29-7
CH2COOH-PEG6-CH2COOH is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands vital for forming PROTAC molecules. This linker enables selective protein degradation by exploiting the ubiquitin-proteasome system within cells.
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Questions
QWhat's the meaning of "< 1 mg/mL refers to the slightly soluble or insoluble"?
AIt means that if the solubility is less than 1 mg/mL
Qwhat frequency should sonication be used?
AIt is recommended to use the conventional ultrasound cleaning frequency
QHow to deal with the insoluble impurities in the product?
AInsoluble impurities, which do not affect the product activity, are recommended to filter out or remove. We will investigate to confirm whether the impurity was introduced during packaging or if it is inherent to the product itself.
QWhether sonication is needed for product dissolution? What if I don't have an ultrasound machine?
Asonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
QHow to use compounds in animal experiments? How to determine dosage and administrative routes?
AThe usage of the same compound may vary for different animal models and disease models. It is recommended to decide the usage based on the experimental purpose and refer to literatures. Common administration routes include intraperitoneal injection, oral gavage, etc. Due to the first-pass effect, compounds that can be administered orally may also be suitable for intraperitoneal injection, but those suitable for intraperitoneal injection may not necessarily be suitable for oral gavage. Dosages for different species can be converted based on tables provided on our official website. It is best to refer to specific literatures for dosages in a particular animal species. Our compounds can be used in both cell and animal experiments, but some compounds may not have literature supporting their use in animal experiments. In such cases, we cannot guarantee efficacy.
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Product Introduction

Bioactivity
Description
CH2COOH-PEG6-CH2COOH is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands vital for forming PROTAC molecules. This linker enables selective protein degradation by exploiting the ubiquitin-proteasome system within cells.
In vitro
PROTACs consist of two distinct ligands linked by a connector: one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
AliasCH2COOH-PEG6-CH2COOH
Chemical Properties
Molecular Weight398.405
FormulaC16H30O11
Cas No.83824-29-7
Relative Density.1.220 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

References

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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