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CHIKV-IN-3
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Catalog No. T61675
CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, with EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It targets host cells to disrupt viral replication while maintaining minimal cytotoxic liability (CC50 > 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1].
CHIKV-IN-3
CHIKV-IN-3
😃Good
Catalog No. T61675
CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, with EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It targets host cells to disrupt viral replication while maintaining minimal cytotoxic liability (CC50 > 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, with EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It targets host cells to disrupt viral replication while maintaining minimal cytotoxic liability (CC50 > 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1]. |
| In vitro | CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits Chikungunya virus (CHIKV) replication with an EC50 of 1.55 μM and shows low cytotoxicity (CC50 = 129.6 μM) [1]. It demonstrates the highest inhibition (approx. 99.99% or 3.9-log reduction in viral titre) at 80 μM [1]. |
| Molecular Weight | 383.95 |
| Formula | C24H30ClNO |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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