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Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor with an IC50 of 0.12 mM, effectively inhibiting drug-resistant fungi variants.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 10-14 weeks | |
50 mg | $1,980 | 10-14 weeks | |
100 mg | $2,500 | 10-14 weeks |
Description | Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor with an IC50 of 0.12 mM, effectively inhibiting drug-resistant fungi variants. |
In vitro | Chitin Synthase Inhibitor 1 (Compound 5a) exhibits broad-spectrum antifungal efficacy, demonstrated by its minimal inhibitory concentrations (MICs): 4 μg/mL against Candida albicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19, and 8 μg/mL against Aspergillus flavus (A. flavus) ATCC 16870 and Cryptococcus neoformans (C. neoformans) ATCC 32719. Additionally, it is effective against drug-resistant fungal strains, with MICs of 32 μg/mL for Fluconazole-resistant C. albicans ATCC 76615R, Fluconazole-resistant A. fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, and Micafungin-resistant C. albicans ATCC 76615R’, and 16 μg/mL for Fluconazole-resistant A. flavus ATCC 16870R [1]. |
Molecular Weight | 409.87 |
Formula | C22H20ClN3O3 |
Storage | Shipping with blue ice. |
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