Chitin Synthase Inhibitor 10, as a potent chitin synthase inhibitor, exhibits remarkable inhibitory activity with an IC50 of 0.11 mM. It also functions as an antifungal agent, demonstrating substantial effectiveness against drug-resistant fungi, including C. albicans and C. neoformans. The compound is useful in researching invasive fungal infections (IFIs) [1].

Compound 9o (chitin synthase inhibitor 10) at 300 µg/mL demonstrates notable inhibitory effects on chitin synthase, evidenced by an IC50 of 0.11 mM. Additionally, it exhibits antifungal properties against C. albicans, A. flavus, A. fumigatus, and C. neoformans, with respective MIC values of 64 µg/mL, 256 µg/mL, 128 µg/mL, and 64 µg/mL. The action of chitin synthase inhibitor 10 is associated with the perturbation of cell wall structure.