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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,270 | 10-14 weeks | |
50 mg | $2,980 | 10-14 weeks | |
100 mg | $4,000 | 10-14 weeks |
Description | Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. |
In vitro | Chk1-IN-5 (compound 3; concentrations of 0.4, 1.2, 3.7, 11.1, 33.3, and 100 nM) effectively blocks Chk1 phosphorylation in HT-29 colon cells[1]. |
In vivo | Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1].Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; Vss=6.4 L/kg; AUC=4531 ng/ml?h)[1]. Animal Model: Baib/c nude mice with HT-29 colon cancer cells[1] |
Alias | Chk1-IN-5 |
Molecular Weight | 383.38 |
Formula | C18H18FN7O2 |
Cas No. | 2120398-39-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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