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Chk1-IN-5
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Catalog No. T37098Cas No. 2120398-39-0
Alias Chk1-IN-5
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
Chk1-IN-5
😃Good
Catalog No. T37098Alias Chk1-IN-5Cas No. 2120398-39-0
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $2,270 | 10-14 weeks | |
| 50 mg | $2,980 | 10-14 weeks | |
| 100 mg | $4,000 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. |
| In vitro | Chk1-IN-5 (compound 3; concentrations of 0.4, 1.2, 3.7, 11.1, 33.3, and 100 nM) effectively inhibits Chk1 phosphorylation in HT-29 colon cells[1]. |
| In vivo | Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells. Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) demonstrates a longer half-life (T1/2=3.8 hours) and higher systemic exposure (CL=2.3 L/hrâ‹…kg; Vss=6.4 L/kg; AUC=4531 ngâ‹…mlâ‹…h)[1]. [Animal Model: Baib/c nude mice with HT-29 colon cancer cells][1]. |
| Alias | Chk1-IN-5 |
| Molecular Weight | 383.38 |
| Formula | C18H18FN7O2 |
| Cas No. | 2120398-39-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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