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cis-Moschamine

cis-Moschamine
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cis-Moschamine

Catalog No. TN6569Cas No. 193224-24-7
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
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Pack SizePriceAvailabilityQuantity
5 mg$300Backorder
1 mL x 10 mM (in DMSO)$240Backorder
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Product Introduction

Bioactivity
Description
cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
In vitro
The antiproliferative effects of n-hexane, chloroform and aqueous methanol extracts prepared from the whole plant of Centaurea arenaria M.B. ex Willd. were investigated against cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF7) and skin epidermoid carcinoma (A431) cells, using the MTT assay. METHODS AND RESULTS: The chloroform extract displayed high tumour cell proliferation inhibitory activity (higher than 85% at 10 μg/mL concentration), and was therefore subjected to a bioassay-guided multistep separation procedure. Flavonoids (eupatilin, eupatorin, 3'-methyleupatorin, apigenin and isokaempferid), lignans (arctigenin, arctiin and matairesinol), the sesquiterpene cnicin, serotonin conjugates (moschamine and cis-Moschamine), β-amyrin and β-sitosterin-β-D-glycopyranoside, identified by means of UV, MS and NMR spectroscopy, were obtained for the first time from this species. CONCLUSIONS: The isolated compounds were also evaluated for their tumour cell growth inhibitory activities on HeLa, MCF7 and A431 cells, and different types of secondary metabolites were found to be responsible for the antitumour effects of the extracts; in addition to moderately active compounds (isokaempferid and moschamine), especially apigenin, eupatorin, arctigenin, arctiin, matairesinol and cnicin exert marked antitumour effects against these cell lines.
Chemical Properties
Molecular Weight352.38
FormulaC20H20N2O4
Cas No.193224-24-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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