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Cl-C6-PEG4-O-CH2COOH

Catalog No. T18639Cas No. 1799506-30-1
Alias PROTAC Linker 4

Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an efficient pegylated PROTAC linker commonly used in the synthesis of chloroanes (HaloPROTACs).

Cl-C6-PEG4-O-CH2COOH

Cl-C6-PEG4-O-CH2COOH

Purity: 99.71%
Catalog No. T18639Alias PROTAC Linker 4Cas No. 1799506-30-1
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an efficient pegylated PROTAC linker commonly used in the synthesis of chloroanes (HaloPROTACs).
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$41In Stock
25 mg$65In Stock
50 mg$105In Stock
100 mg$169In Stock
500 mg$423In Stock
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Purity:99.71%
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Product Introduction

Bioactivity
Description
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an efficient pegylated PROTAC linker commonly used in the synthesis of chloroanes (HaloPROTACs).
In vitro
PROTACs comprise two distinct ligands linked by a connector: one ligand targets an E3 ubiquitin ligase, and the other binds to the target protein. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
AliasPROTAC Linker 4
Chemical Properties
Molecular Weight370.87
FormulaC16H31ClO7
Cas No.1799506-30-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 90 mg/mL (240 mM), Sonication is recommended.
DMSO: 90 mg/mL (240 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.6964 mL13.4818 mL26.9636 mL134.8181 mL
5 mM0.5393 mL2.6964 mL5.3927 mL26.9636 mL
10 mM0.2696 mL1.3482 mL2.6964 mL13.4818 mL
20 mM0.1348 mL0.6741 mL1.3482 mL6.7409 mL
50 mM0.0539 mL0.2696 mL0.5393 mL2.6964 mL
100 mM0.0270 mL0.1348 mL0.2696 mL1.3482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Cl-C6-PEG4-O-CH2COOH
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