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CL 316243 free acid

Name: CL 316243 free acid
Brand: TargetMol
SKU: T88808
Price: 41 USD
Availability: InStock
Rating: 4.5 (1 reviews)

CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.

Catalog No. T88808Cas No. 183720-02-7

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CL 316243 free acid

Catalog No. T88808Cas No. 183720-02-7

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Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.
In vitro	CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.
In vivo	Administering CL316243 free acid via subcutaneous injection (Subcutaneous Injectio;0.1 mg/kg/d;1 week) ignificantly increases the mRNA and protein expression levels of UCP1 in brown adipose tissue (BAT), independently of diet. In the study, male C57BL/6J mice were either fed a high-fat diet (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks. The dose of CL316243 was 0.1 mg/kg/day. This treatment was found to greatly enhance resistance against obesity in these mice.

Chemical Properties

Molecular Weight	421.83
Formula	C₂₀H₂₀ClNO₇
Cas No.	183720-02-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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