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CL 316243 free acid

Name: CL 316243 free acid
Brand: TargetMol
SKU: T88808
Price: 42 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T88808Cas No. 183720-02-7

CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.

CL 316243 free acid

😃Good

Catalog No. T88808Cas No. 183720-02-7

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.
In vitro	CL 316243 free acid exhibits an IC 50 of 0.6 μM and 1 μM for rat heart and rat soleus muscle, respectively. Additionally, it inhibits spontaneous contractions in isolated rat detrusor muscle strips in a concentration-dependent manner, with an average concentration for 50% maximal inhibition at 2.65 nM.
In vivo	Administering CL316243 free acid via subcutaneous injection (Subcutaneous Injectio;0.1 mg/kg/d;1 week) ignificantly increases the mRNA and protein expression levels of UCP1 in brown adipose tissue (BAT), independently of diet. In the study, male C57BL/6J mice were either fed a high-fat diet (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks. The dose of CL316243 was 0.1 mg/kg/day. This treatment was found to greatly enhance resistance against obesity in these mice.

Chemical Properties

Molecular Weight	421.83
Formula	C₂₀H₂₀ClNO₇
Cas No.	183720-02-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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