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CL 316243
CL316243 is a highly potent and selective agonist of β3-adrenoceptor with an EC50 of 3 nM. It effectively stimulates adipocyte lipolysis, increases brown adipose tissue thermogenesis and metabolic rate, and holds potential for the treatment of obesity, diabetes, and [urge urinary incontinence].
Catalog No. T10830Cas No. 138908-40-4
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Purity:99.68%
ee:100%
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CL 316243
Catalog No. T10830Cas No. 138908-40-4
CL316243 is a highly potent and selective agonist of β3-adrenoceptor with an EC50 of 3 nM. It effectively stimulates adipocyte lipolysis, increases brown adipose tissue thermogenesis and metabolic rate, and holds potential for the treatment of obesity, diabetes, and [urge urinary incontinence].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $347 | In Stock | |
| 50 mg | $555 | In Stock | |
| 100 mg | $888 | In Stock | |
| 500 mg | $1,770 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CL316243 is a highly potent and selective agonist of β3-adrenoceptor with an EC50 of 3 nM. It effectively stimulates adipocyte lipolysis, increases brown adipose tissue thermogenesis and metabolic rate, and holds potential for the treatment of obesity, diabetes, and [urge urinary incontinence]. |
| Targets&IC50 | β3-adrenoceptor:(EC50)3 nM |
| In vitro | CL 316243 displays binding affinities with IC50 values of 1 μM and 0.6 μM for rat soleus muscle and rat heart respectively. CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration-dependent manner with a mean concentration inhibiting 50% of the maximal response of 2.65 nM [1]. |
| In vivo | CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 week) elevates the mRNA and protein expression levels of BAT in UCP1 [2]. |
| Molecular Weight | 465.79 |
| Formula | C20H18ClNNa2O7 |
| Cas No. | 138908-40-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 80 mg/mL (171.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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