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Clopidogrel thiolactone
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Catalog No. T5501Cas No. 1147350-75-1
Alias 2-oxoclopidogrel
Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the active metabolic intermediate resulting from the first oxidative activation of Clopidogrel.
Clopidogrel thiolactone
😃Good
Catalog No. T5501Alias 2-oxoclopidogrelCas No. 1147350-75-1
Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the active metabolic intermediate resulting from the first oxidative activation of Clopidogrel.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $173 | 5 days | |
| 5 mg | $297 | 5 days | |
| 10 mg | $469 | 5 days | |
| 1 mL x 10 mM (in DMSO) | $327 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Clopidogrel thiolactone (2-oxoclopidogrel) is a potent P2Y12 receptor inhibitor and a potent antiplatelet aggregation compound.Clopidogrel thiolactone is the active metabolic intermediate resulting from the first oxidative activation of Clopidogrel. |
| In vivo | Clopidogrel thiolactone holds great promise as a more potent and a safer antiplatelet agent that might have the following advantages over clopidogrel: (1) no drug resistance for CYP2C19 poor metabolizers; (2) lower dose-related toxicity due to a much lower effective dose; (3) faster onset of action. Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) exhibits good biological availability and pharmacokinetic parameters[2]. |
| Alias | 2-oxoclopidogrel |
| Molecular Weight | 337.82 |
| Formula | C16H16ClNO3S |
| Cas No. | 1147350-75-1 |
| Smiles | COC(=O)[C@@H](N1CCC2SC(=O)C=C2C1)c1ccccc1Cl |
| Relative Density. | 1.39 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2 mg/mL (5.92 mM), Sonication and heating are recommended. DMSO: 30 mg/mL (88.80 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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