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CM-414

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CM-414

Catalog No. T27051Cas No. 1624792-70-6

CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatment of Tg2576 mice with CM-414 diminished brain Aβ and tau phosphorylation (pTau) levels, increased the inactive form of GSK3β, reverted the decrease in dendritic spine density on hippocampal neurons, and reversed their cognitive deficits, at least in part by inducing the expression of genes related to synaptic transmission.

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Pack Size	Price	Availability
25 mg	$2,270	10-14 weeks
50 mg	$2,980	10-14 weeks
100 mg	$4,000	10-14 weeks

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Product Introduction

Bioactivity

Description	CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatment of Tg2576 mice with CM-414 dimini
Alias	CM 414, CM414

Chemical Properties

Molecular Weight	439.51
Formula	C23H29N5O4
Cas No.	1624792-70-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

CM-414