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Complement factor D-IN-1

Name: Complement factor D-IN-1
Brand: TargetMol
SKU: T16898
Price: 33 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16898Cas No. 1386455-76-0

Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.

Complement factor D-IN-1

😃Good

Catalog No. T16898Cas No. 1386455-76-0

Pack Size	Price	Availability	Quantity
5 mg	$390	7-10 days
1 mL x 10 mM (in DMSO)	$456	7-10 days

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Product Introduction

Bioactivity

Description	Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.
Targets&IC50	FD:0.006 μM, MAC:0.05 μM
In vitro	Complement factor D-IN-1 displays similar potency against human and monkey FD (IC50s: 0.005 μM in FD thioesterolytic assays and 0.011 μM in 50% serum MAC deposition assays for both human and monkey) [1].
In vivo	Complement factor D-IN-1 shows an excellent oral PK profile in Sprague–Dawley rats and, following an oral dose (10 mg/kg) in Brown Norway rats, demonstrates a good distribution and sustained exposure in ocular tissues including the neural retina. Mean exposure levels in plasma, the PEC, and the retina at 6 h after dosing are 0.36, 0.43, and 0.09 μM, respectively [1].

Chemical Properties

Molecular Weight	483.32
Formula	C₂₁H₁₉BrN₆O₃
Cas No.	1386455-76-0
Relative Density.	1.82 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (517.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0690 mL	10.3451 mL	20.6902 mL	103.4511 mL
5 mM	0.4138 mL	2.0690 mL	4.1380 mL	20.6902 mL
10 mM	0.2069 mL	1.0345 mL	2.0690 mL	10.3451 mL
20 mM	0.1035 mL	0.5173 mL	1.0345 mL	5.1726 mL
50 mM	0.0414 mL	0.2069 mL	0.4138 mL	2.0690 mL
100 mM	0.0207 mL	0.1035 mL	0.2069 mL	1.0345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Complement factor D IN 1Complement factor DIN1Complement factor D-IN-1