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Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, blocking its interaction with the FXa active site. Injections of Concizumab increase thrombin in blood, thereby preventing and treating hemophilia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $228 | In Stock | |
5 mg | $589 | In Stock | |
10 mg | $967 | In Stock | |
25 mg | $1,430 | In Stock | |
50 mg | $1,930 | In Stock |
Description | Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, blocking its interaction with the FXa active site. Injections of Concizumab increase thrombin in blood, thereby preventing and treating hemophilia. |
In vitro | In a concentration-dependent manner, Concizumab increases the peak value of thrombin [1]. |
In vivo | In cynomolgus monkeys, Concizumab (i.v./s.c.) blocked the interaction between TFPI and FXa active site [2]. |
Alias | NN 7415, mAb 2021 |
Molecular Weight | 145.76 kDa |
Cas No. | 1312299-39-0 |
Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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