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Coproporphyrin III

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Catalog No. T19247Cas No. 14643-66-4
Alias Zincphyrin

Coproporphyrin III is a derivative of porphyrin.

Coproporphyrin III

Coproporphyrin III

😃Good
Catalog No. T19247Alias ZincphyrinCas No. 14643-66-4
Coproporphyrin III is a derivative of porphyrin.
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Product Introduction

Bioactivity
Description
Coproporphyrin III is a derivative of porphyrin.
In vitro
Coproporphyrin III methyl ester is repeatedly isolated in a considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal, or chemical poisoning or liver disease [1]. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), the addition of insulin causes a striking increase in the accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolish the uroporphyrin I accumulation and increases coproporphyrin III [2].
In vivo
Urinary porphyrin and DMA profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control [3].
AliasZincphyrin
Chemical Properties
Molecular Weight654.72
FormulaC36H38N4O8
Cas No.14643-66-4
Relative Density.1.366 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 83.3 mg/mL (127.23 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5274 mL7.6369 mL15.2737 mL76.3685 mL
5 mM0.3055 mL1.5274 mL3.0547 mL15.2737 mL
10 mM0.1527 mL0.7637 mL1.5274 mL7.6369 mL
20 mM0.0764 mL0.3818 mL0.7637 mL3.8184 mL
50 mM0.0305 mL0.1527 mL0.3055 mL1.5274 mL
100 mM0.0153 mL0.0764 mL0.1527 mL0.7637 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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