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Coumermycin A1

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Catalog No. T36106Cas No. 4434-05-3

Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.

Coumermycin A1

Coumermycin A1

😃Good
Catalog No. T36106Cas No. 4434-05-3
Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.
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Product Introduction

Bioactivity
Description
Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.
In vitro
Coumermycin A1-induced activation of the JAK2 signaling pathway elevates SCOS2 mRNA levels while decreasing the mRNA level of the leptin receptor[1].
Chemical Properties
Molecular Weight1110.092
FormulaC55H59N5O20
Cas No.4434-05-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (45.04 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9008 mL4.5041 mL9.0083 mL45.0413 mL
5 mM0.1802 mL0.9008 mL1.8017 mL9.0083 mL
10 mM0.0901 mL0.4504 mL0.9008 mL4.5041 mL
20 mM0.0450 mL0.2252 mL0.4504 mL2.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Coumermycin A1Coumermycin A-1
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