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COX-2-IN-44
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Catalog No. T89018
COX-2-IN-44 is an effective and orally active COX-2 inhibitor, with IC50 values of 0.18 µM for COX-2 and 1.14 µM for COX-1. Additionally, COX-2-IN-44 exhibits anti-inflammatory properties.
COX-2-IN-44
COX-2-IN-44
😃Good
Catalog No. T89018
COX-2-IN-44 is an effective and orally active COX-2 inhibitor, with IC50 values of 0.18 µM for COX-2 and 1.14 µM for COX-1. Additionally, COX-2-IN-44 exhibits anti-inflammatory properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | COX-2-IN-44 is an effective and orally active COX-2 inhibitor, with IC50 values of 0.18 µM for COX-2 and 1.14 µM for COX-1. Additionally, COX-2-IN-44 exhibits anti-inflammatory properties. |
| Targets&IC50 | COX-2:0.18 μM, COX-1:1.14 μM |
| In vivo | COX-2-IN-44 (compound 6b) administered orally at a dosage of 10 mg/kg, demonstrated significant anti-inflammatory effects in an animal model utilizing twenty-five adult albino Wistar rats with paw edema [1]. The compound not only decreased paw volume progressively, with percentage reductions in edema recorded at 61.62%, 54.34%, and 44.64% after the 1st, 2nd, and 3rd hour respectively, but also lowered PGE2 plasma levels by 42.6% and reduced IL-1β levels by 32.0%. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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