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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $350 | Backorder | |
10 mg | $546 | Backorder | |
25 mg | $1,067 | Backorder |
Description | CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2]. Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 hydrochloride has the potential for inflammatory bowel disease research[1]. [1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413.[2]. Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611. |
In vitro | Tryptase, a trypsin-like serine protease predominantly located in the secretory granules of human mast cells, plays a crucial role in the body's immune response. CRA-2059 hydrochloride, due to its properties, shows promise for research in inflammatory bowel disease (IBD). |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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