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CTS-1027

CTS-1027
CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
Catalog No. T15015Cas No. 193022-04-7

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CTS-1027

Catalog No. T15015Cas No. 193022-04-7

CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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2 mg$975 days
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Product Introduction

Bioactivity
Description
CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
Targets&IC50
MMP2:0.2 nM, MMP3:9.5 nM, MMP13:0.5 nM, MMP12:0.7 nM, MMP14:15 nM, MMP8:0.9 nM
In vivo
CTS-1027 improves overall animal survival following 14 days of BDL in mice [1]. CTS-1027 effectively reduces features of cholestatic liver injury, the hepatocyte apoptosis, and markers of hepatic fibrogenesis in the BDL mouse. The terminal plasma concentration of RS-130830 is 311 nM, in male animals treated for 8 weeks. RS-130830(8 weeks; male mice ) treatment causes an 89% increase in plasma triglyceride concentration. But there is no corresponding effect in female mice treated for 12 weeks. The plaque lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks [2].
AliasRS 130830, Ro 1130830
Chemical Properties
Molecular Weight425.88
FormulaC19H20ClNO6S
Cas No.193022-04-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (234.81 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3481 mL11.7404 mL23.4808 mL117.4040 mL
5 mM0.4696 mL2.3481 mL4.6962 mL23.4808 mL
10 mM0.2348 mL1.1740 mL2.3481 mL11.7404 mL
20 mM0.1174 mL0.5870 mL1.1740 mL5.8702 mL
50 mM0.0470 mL0.2348 mL0.4696 mL2.3481 mL
100 mM0.0235 mL0.1174 mL0.2348 mL1.1740 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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