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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $198 | 35 days | |
5 mg | $695 | 35 days | |
10 mg | $1,180 | 35 days |
Description | CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020) |
Molecular Weight | 371.13 |
Formula | C11H10IN5O2 |
Cas No. | 2400954-16-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 30 mg/mL DMSO: 30 mg/mL DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL |
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