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Cyclo(Tyr-Phe)
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Catalog No. TN6689Cas No. 5147-17-1
Cyclo-(Phe-Tyr) shows anticoagulant activities.
Cyclo(Tyr-Phe)
😃Good
Catalog No. TN6689Cas No. 5147-17-1
Cyclo-(Phe-Tyr) shows anticoagulant activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $730 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $500 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cyclo-(Phe-Tyr) shows anticoagulant activities. |
| In vitro | To study the in vitro anticoagulant activity of cyclodipeptide(cyclo-(Tyr-Leu),cyclo-(PhePhe) and cyclo-(Phe-Tyr)) isolated from Sparganium stoloniferum Buch.-Ham. METHODS AND RESULTS:The special kits were used to measure anticoagulant activity with platelet poor plasma collected from abdominal aorta of male SD rats,including prothrombin time(PT),activated partial thromboplastin time(APTT) and thrombin time(TT).PT,APTT,TT were prolonged by the addition of cyclo-(Tyr-Leu),cyclo-(Phe-Phe) and Cyclo(Tyr-Phe). The former two presented no dose-effect relationship but the latter did. CONCLUSIONS:Of three cyclodipeptides from S. stoloniferum,all the three show anticoagulant activities with cyclo-(Phe-Tyr) being by far the most effective. |
| Molecular Weight | 310.353 |
| Formula | C18H18N2O3 |
| Cas No. | 5147-17-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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