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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $1,490 | 10-14 weeks |
Description | D-Cl-amidine hydrochloride is a potent and highly selective inhibitor of PAD1. It exhibits excellent tolerance and does not induce significant toxicity [1]. |
In vitro | D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells [1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis [1]. |
In vivo | Administered intravenously (iv) at a dose of 2.5 mg/kg, D-Cl-amidine remains detectable in serum, exhibiting concentrations of approximately 21 nM after 2 hours and around 10 nM at 4 hours. Similarly, when administered intraperitoneally (ip) at a 10 mg/kg dosage, D-Cl-amidine's presence in blood serum is sustained, with concentrations approximately 10 nM at the 4-hour mark [1]. |
Molecular Weight | 347.24 |
Formula | C14H20Cl2N4O2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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