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Dazopride

Dazopride
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Dazopride

Catalog No. T10963Cas No. 70181-03-2
Dazopride [LY-237733, AHR-5531] is an antiemetic agent with the chemical composition C15H15N5O2S and a molecular weight of 329.38 g/mol. It appears as white to off-white crystalline powder, melting at 159–162°C, and is soluble in water (forceps method) and organic solvents (chlorinated solvents).
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Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Dazopride [LY-237733, AHR-5531] is an antiemetic agent with the chemical composition C15H15N5O2S and a molecular weight of 329.38 g/mol. It appears as white to off-white crystalline powder, melting at 159–162°C, and is soluble in water (forceps method) and organic solvents (chlorinated solvents).
In vivo
Dasopride (0.3 mg / kg) can significantly enhance gastric emptying. In the gastric emptying test, its efficacy is about six times higher than that of metoclopramide. Dazopril (0.3-10.0 mg / kg, intravenous) produced dose-related increases in anal motility mainly by increasing the anal contraction amplitude in three sober dogs. Dazopril significantly reduced the frequency of vomiting in the control group. Doxolipril (5 mg / kg, intraperitoneal injection) antagonizes tetralin induced vomiting, but not 0.25-2.5 mg / kg. Although larger doses of 1.0 mg / kg eliminated or weakened its response, dazopril could not change cisplatin-induced vomiting at 0.1 mg / kg (iv), while dazopride at 5.0 mg / kg antagonized vomiting in all animals development of.
AliasAHR-5531
Chemical Properties
Molecular Weight326.82
FormulaC15H23ClN4O2
Cas No.70181-03-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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