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DBCO-NH-(CH2)4COOH

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Catalog No. T17755Cas No. 2375193-74-9

DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].

DBCO-NH-(CH2)4COOH

DBCO-NH-(CH2)4COOH

😃Good
Catalog No. T17755Cas No. 2375193-74-9
DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].
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Product Introduction

Bioactivity
Description
DBCO-NH-(CH2)4COOH is a synthetic alkyl chain-based PROTAC linker, which finds utility in PROTAC synthesis[1].
In vitro
PROTACs consist of two ligands linked together; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
Chemical Properties
Molecular Weight404.46
FormulaC24H24N2O4
Cas No.2375193-74-9
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

DBCO-NH-(CH2)4COOHDBCO NH (CH2)4COOHDBCO-NH-(CH-2)4COOHDBCONH(CH2)4COOH
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