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DDC-01-163

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Catalog No. T203074Cas No. 2140806-84-2

DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM.

DDC-01-163

DDC-01-163

😃Good
Catalog No. T203074Cas No. 2140806-84-2
DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM.
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Product Introduction

Bioactivity
Description
DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM.
In vitro
DDC-01-163 (0-10 μM) inhibits the proliferation of L858R/T790M EGFR mutant Ba/F3 cells in a concentration-dependent manner, without affecting wild-type EGFR-Ba/F3 cells. In L858R/T790M cells, DDC-01-163 shows IC 50 /EC 50 values for EGFR of 96 nM.
Chemical Properties
Molecular Weight942.05
FormulaC49H51N9O9S
Cas No.2140806-84-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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