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DDR1-IN-5

🥰Excellent
Catalog No. T40062Cas No. 2416022-90-5
Alias DDR1-IN-5

DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.

DDR1-IN-5

DDR1-IN-5

🥰Excellent
Catalog No. T40062Alias DDR1-IN-5Cas No. 2416022-90-5
DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.
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Product Introduction

Bioactivity
Description
DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 demonstrates remarkable anti-cancer activity. Its inhibitory potency against DDR1 (IC 50 = 7.36 nM) makes it a promising compound for targeted therapy in cancer treatment.
Targets&IC50
DDR1:7.36 nM (IC50)
In vitro
DDR1-IN-5 (compound 121), when administered for 24 hours, hampers the production of collagen in human hepatic stellate LX-2 cells, demonstrating an inhibitory concentration (IC 50) of 62 nM[1]. A prolonged exposure of 72 hours to DDR1-IN-5 reveals cytotoxic effects on LX-2 cells, with a cytotoxic concentration (CC 50) exceeding 40 μM[1].
AliasDDR1-IN-5
Chemical Properties
Molecular Weight434.382
FormulaC22H13F3N6O
Cas No.2416022-90-5
Relative Density.1.45 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

DDR-1-IN-5DDR1IN5DDR1 IN 5
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