Dendrotoxin-I (DTX-I) TFA is an effective blocker of K+ channels, displaying IC50 values of 0.13-50 nM against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin also holds potential for use in cancer research.

Kv1.6:0.13-50 nM, Kv1.2:0.13-50 nM, Kv1.1:0.13-50 nM

Dendrotoxin-I (5 mg/kg;) TFA, when combined with hyperthermia, demonstrated notable inhibition of tumor growth. In an animal model using nude mice implanted with MCF-7 cells [3], the compound was administered intravenously at a dosage of 5 mg/kg. Initially, it exhibited significant effects in suppressing tumor growth, although it failed to maintain this inhibitory effect in the later stages of the treatment.