Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells, without significantly affecting mature osteoblasts. Dentonin is valuable for research on phosphate homeostasis and bone metabolism.

MEPE, a secreted glycophosphoprotein belonging to the SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) family, plays a crucial role in regulating bone mass and osteoblast activity. Dentonin, at concentrations of 3-30 μg/ml over 2-24 hours, significantly enhances cell proliferation and promotes cell adhesion, though it does not affect the overall number of cells adhered. Additionally, Dentonin markedly increases osteoblast spreading, demonstrating significantly larger cell areas compared to other treatments.