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Dichlorophenyl-ABA

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Dichlorophenyl-ABA

Catalog No. T15116Cas No. 18201-65-5

Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.

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Pack Size	Price	Availability
25 mg	$1,300	6-8 weeks
50 mg	$1,690	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description

Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.

In vitro

Dichlorophenyl-ABA can prevent L55P aggregate formation in the conditioned medium. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP). However, it needs to undergo further stages of drug development to overcome its toxicity.

Chemical Properties

Molecular Weight	282.12
Formula	C13H9Cl2NO2
Cas No.	18201-65-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

Dichlorophenyl ABADichlorophenyl-ABADichlorophenylABA