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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,300 | 6-8 weeks | |
50 mg | $1,690 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells. |
In vitro | Dichlorophenyl-ABA can prevent L55P aggregate formation in the conditioned medium. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP). However, it needs to undergo further stages of drug development to overcome its toxicity. |
Molecular Weight | 282.12 |
Formula | C13H9Cl2NO2 |
Cas No. | 18201-65-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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