Diketone-PEG12-DBCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

PROTACs feature two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets a specific protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade these target proteins[1].