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Dirocaftor

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Catalog No. T39596Cas No. 2137932-23-9
Alias PTI-808

Dirocaftor (PTI-808) is a CFTR potentiator that enhances CFTR protein function by activating chloride channels, with potential utility for cystic fibrosis (CF) research.

Dirocaftor

Dirocaftor

😃Good
Catalog No. T39596Alias PTI-808Cas No. 2137932-23-9
Dirocaftor (PTI-808) is a CFTR potentiator that enhances CFTR protein function by activating chloride channels, with potential utility for cystic fibrosis (CF) research.
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10 mg$1,024Backorder
25 mg$2,117Backorder
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Product Introduction

Bioactivity
Description
Dirocaftor (PTI-808) is a CFTR potentiator that enhances CFTR protein function by activating chloride channels, with potential utility for cystic fibrosis (CF) research.
In vitro
When co-administered with Nesolicaftor and Posenacaftor, Dirocaftor enhances the functionality of CFTR to levels approaching normalcy[2].
AliasPTI-808
Chemical Properties
Molecular Weight424.647
FormulaC22H28N2O3Si2
Cas No.2137932-23-9
Relative Density.1.16 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

PTI 808DirocaftorPTI808
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