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DL-AP7

Name: DL-AP7
Brand: TargetMol
SKU: T22734
Price: 41 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T22734Cas No. 85797-13-3

DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].

DL-AP7

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Catalog No. T22734Cas No. 85797-13-3

DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].

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Product Introduction

Bioactivity

Description	DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].
In vivo	DL-AP7, when administered intracerebroventricularly (ICV), inhibits convulsions triggered by NMDA with an effective dose (ED 50) of 0.22 nmol/mouse. Additionally, it detrimentally affects the ability of mice to learn in a passive avoidance task [1].

Chemical Properties

Molecular Weight	225.181
Formula	C₇H₁₆NO₅P
Cas No.	85797-13-3
Relative Density.	1.39 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

1eq. NaOH: 100 mM

Solution Preparation Table

1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	4.4409 mL	22.2044 mL	44.4087 mL	222.0436 mL
5 mM	0.8882 mL	4.4409 mL	8.8817 mL	44.4087 mL
10 mM	0.4441 mL	2.2204 mL	4.4409 mL	22.2044 mL
20 mM	0.2220 mL	1.1102 mL	2.2204 mL	11.1022 mL
50 mM	0.0888 mL	0.4441 mL	0.8882 mL	4.4409 mL
100 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2204 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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