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DL 175

Catalog No. T37907Cas No. 2487253-25-6

Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

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Pack Size	Price	Availability	Quantity
10 mg	$1,289	Backorder
50 mg	$1,980	Backorder

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	299.75
Formula	C17H14ClNO2
Cas No.	2487253-25-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29.98 mg/mL (100 mM)

Ethanol: 29.98 mg/mL (100 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3361 mL	16.6806 mL	33.3611 mL	166.8057 mL
5 mM	0.6672 mL	3.3361 mL	6.6722 mL	33.3611 mL
10 mM	0.3336 mL	1.6681 mL	3.3361 mL	16.6806 mL
20 mM	0.1668 mL	0.8340 mL	1.6681 mL	8.3403 mL
50 mM	0.0667 mL	0.3336 mL	0.6672 mL	3.3361 mL
100 mM	0.0334 mL	0.1668 mL	0.3336 mL	1.6681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DL175DL-175DL 175