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DMHCA
🥰Excellent
Catalog No. T40898Cas No. 79066-03-8
DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression.
DMHCA
🥰Excellent
Purity: 99.80%
Catalog No. T40898Cas No. 79066-03-8
DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $29 | In Stock |
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Purity:99.80%
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Product Introduction
Bioactivity
Chemical Properties
| Description | DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression. |
| In vitro | Treatment of diabetic CD34+ cells with 10 μM DMHCA restored cell membrane fluidity to non-diabetic baseline levels. DMHCA restored bone marrow-derived TNF-α and IL-3 levels to baseline and significantly reduced CCL-2 production in bone marrow supernatant and systemic circulation. In addition, DMHCA increased the number of circulating vascular progenitor cells (CACs) in the bone marrow and peripheral circulation and facilitated the migration of vascular repair cells into the peripheral circulation. [1] |
| In vivo | DMHCA was able to restore cholesterol homeostasis in the diabetic retina by oral administration of 8 mg/kg/day for 6 months. In diabetic retina, DMHCA significantly increased the levels of endogenous LXR ligand, norethisterol and total oxidized sterols. [1] |
| Molecular Weight | 401.63 |
| Formula | C26H43NO2 |
| Cas No. | 79066-03-8 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(N(C)C)=O)C)[H])[H] |
| Relative Density. | 1.06 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (12.45 mM.), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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