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DMP 777

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DMP 777

Catalog No. T15144Cas No. 157341-41-8

DMP 777 is an orally active inhibitor of human leukocyte elastase.

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Pack Size	Price	Availability
2 mg	$95	5 days
5 mg	$163	5 days
1 mL x 10 mM (in DMSO)	$227	5 days

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Product Introduction

Bioactivity

Description	DMP 777 is an orally active inhibitor of human leukocyte elastase.
In vivo	DMP-777-treated animals show marked foveolar hyperplasia in the fundus with the prominent expansion of diastase-resistant, PAS-positive surface mucous cells. DMP-777-treated rats display a marked reduction in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. When DMP-777 is coadministered with omeprazole, there is an obvious decrease in BrdU-positive S-phase cells compared with rats that received DMP-777 alone [1]. After DMP-777(40 mg/kg; p.o.; monkeys) treatment, the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo [2]. Mist1-/- mice treated with DMP-777 show fewer chief cells to SPEM transitions and which treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice [3].
Alias	L-694458

Chemical Properties

Molecular Weight	564.67
Formula	C31H40N4O6
Cas No.	157341-41-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 38.33 mg/mL (67.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7709 mL	8.8547 mL	17.7095 mL	88.5473 mL
5 mM	0.3542 mL	1.7709 mL	3.5419 mL	17.7095 mL
10 mM	0.1771 mL	0.8855 mL	1.7709 mL	8.8547 mL
20 mM	0.0885 mL	0.4427 mL	0.8855 mL	4.4274 mL
50 mM	0.0354 mL	0.1771 mL	0.3542 mL	1.7709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

L694458L 694458DMP777DMP 777DMP-777