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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $95 | 5 days | |
5 mg | $163 | 5 days | |
1 mL x 10 mM (in DMSO) | $227 | 5 days |
Description | DMP 777 is an orally active inhibitor of human leukocyte elastase. |
In vivo | DMP-777-treated animals show marked foveolar hyperplasia in the fundus with the prominent expansion of diastase-resistant, PAS-positive surface mucous cells. DMP-777-treated rats display a marked reduction in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. When DMP-777 is coadministered with omeprazole, there is an obvious decrease in BrdU-positive S-phase cells compared with rats that received DMP-777 alone [1]. After DMP-777(40 mg/kg; p.o.; monkeys) treatment, the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo [2]. Mist1-/- mice treated with DMP-777 show fewer chief cells to SPEM transitions and which treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice [3]. |
Alias | L-694458 |
Molecular Weight | 564.67 |
Formula | C31H40N4O6 |
Cas No. | 157341-41-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 38.33 mg/mL (67.88 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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