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Docebenone
😃Good
Catalog No. T15155Cas No. 80809-81-0
Alias AA 861
Docebenone is a selective and orally active inhibitor of 5-LO.
Docebenone
😃Good
Catalog No. T15155Alias AA 861Cas No. 80809-81-0
Docebenone is a selective and orally active inhibitor of 5-LO.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $390 | 8-10 weeks | |
| 25 mg | $1,330 | 8-10 weeks | |
| 50 mg | $1,740 | 8-10 weeks | |
| 100 mg | $2,440 | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | $397 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Docebenone is a selective and orally active inhibitor of 5-LO. |
| In vitro | Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with the medium [1]. Docebenone at 10-200 μM increases [Ca2+]i concentration-dependently [2]. |
| In vivo | In monkeys, Docebenone (0.01-10 μM) suppresses the release of SRS-A by 55-97% with a dose-dependently manner. The antigen-induced SRS-A release from these fragments is dose-dependently inhibited by 25-93% of Docebenone (0.01-10 μM) [4]. Docebenone may protect experimental acute necrotizing pancreatitis in rats [3]. |
| Alias | AA 861 |
| Molecular Weight | 326.43 |
| Formula | C21H26O3 |
| Cas No. | 80809-81-0 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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